Journal of Organic Chemistry p. 4508 - 4514 (1985)
Update date:2022-07-31
Topics:
Hoeve, Wolter ten
Wynberg, Hans
A systematic investigation has been started with the twofold purpose of synthesizing efficient resolving agents and of gaining an insight into the factors that contribute to successful resolutions.We report on the synthesis, resolution, and application of a number of chiral cyclic phosphoric acids.Among these acids, 4-(2-chlorophenyl)-5,5-dimethyl-2-hydroxy-1,3,2-dioxaphosphorinane 2-oxide (7A) is an efficient resolving agent, being useful for the resolution of amines and amino acids.Acid chloride 20 is a useful reagent for the determination of the ee of chiral amines.The absolute configuration of (-)-7A was determined through an X-ray structure determination of its salt with (-)-(p-hydroxyphenyl)glycine.
View MoreJintan Jinnuo Chemical Co., Ltd.
Contact:+86-519-80199901
Address:Room 1804, Building 1, Huacheng Business Plaza, Jintan, Jiangsu, China
KangZhiYuan Pharmaceutical Company Limited
Contact:(Sabrina)86-20-85273232
Address:4th floor, building B, Dadi industry zone, Tangxia, Tianhe, Guangzhou, China
Jinan Yijialian Economic and Trade Development Co., Ltd.
Contact:+86 0531-66729596
Address:jinan
Henan PURUI Pharmaceutical Co., Ltd.
website:http://www.puruipharm.com
Contact:17739583555
Address:Yezhuangqiao,Xihua town, Henan province
Chemvon Biotechnology Co. Ltd.
website:http://www.chemvon.com
Contact:86-21-58550039;86-21-31268550-8004
Address:Suite B-10#, 6999 Chuansha Road, Pudong District, Shanghai 201202, China
Doi:10.1016/j.tet.2017.01.029
(2017)Doi:10.1002/jps.2600800917
(1991)Doi:10.1016/S0040-4039(01)80797-8
(1985)Doi:10.1016/S0040-4039(99)00173-2
(1999)Doi:10.1021/ja00261a010
(1986)Doi:10.1021/jo00258a003
(1988)