10.1002/adsc.201800455
Advanced Synthesis & Catalysis
E.coli (SpPDC) in 100 mL potassium phosphate buffer (pH
6.5, 50 mM) containing dialdehyde (1.00 mmol of 1a or 1b),
ThDP (5 mg, 0.01 mmol) and MgSO4 (62 mg, 0.25 mmol).
The reactions were performed at 30°C and 200 rpm and
monitored by GC analysis. After dialdehyde reacted
completely, the pH of the reaction mixtures was adjusted
to 8.0 with 1 M NaOH. Then glucose (595 mg, 3.00 mmol),
25 mg of NADP+ or NAD+, 20 U of purified ADHs, GDH
(200 mg, 80 U) were added into the reaction mixtures. The
reactions were performed at 200 rpm and 30°C and
monitored by GC analysis. Once the reaction was finished,
the reaction solution was centrifuged to remove precipitate,
and the solutions were saturated with NaCl and extracted
with n-butyl alcohol (100 mL3) three times. The
combined organic extracts were dried over Na2SO4, filtered
and evaporated in vacuo. The desired product was obtained
after purification by column silica gel chromatography.
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Acknowledgements
This work was financially supported by the Youth Innovation
Promotion Association of the Chinese Academy of Sciences
(Grant No. 2016166), the National Natural Science Foundation
of China (Grant No. 21472232) and Tianjin Municipal Science
and
Technology
Commission
(15PTGCCX00060
and
15PTCYSY00020). Special thanks go to Professor Peter C. K.
Lau of our institute for his helping with the revision of the
manuscript.
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