ORDER
REPRINTS
724
Iyer and Kulkarni
This is a facile, neutral, cleaner reaction condition and catalyst for the
selective reduction of azides and nitro compounds to amines and amides
compared to the other available reagents and reactions.[1] The yields and
selectivity are comparable to the reported methods and the cost of Mo(CO)6
(Aldrich: $52.50 for 10 g, Strem: $40.00 for 25 g) is reasonable for the
laboratory use of the reagent.
EXPERIMENTAL PROCEDURE
4-Chlorophenyl azide (0.153 g, 1 mmol) and Mo(CO)6 (0.264 g, 1 mmol)
was refluxed in ethanol (15 ml) for 2–24 h and monitored by TLC. After
completion, the reaction mixture was concentrated on a rotary evaporator,
extracted with ethyl acetate, filtered over celite, concentrated and purified by
column chromatography over silica gel (100–200 mesh) to give 4-chloro
aniline (0.112 g, 88 %).
ACKNOWLEDGMENTS
We thank the DST for a research grant and GMK thanks CSIR for a SRF.
REFERENCES
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