European Journal of Organic Chemistry
10.1002/ejoc.201900311
FULL PAPER
arylboronic acids or arylboronic esters with very good to excellent
yields in short reaction times. This methodology is free of strong
bases, transition metals and strong oxidant such hydrogen
peroxide, involves the use of the greenest solvent, i.e., water,
generating less toxic waste which is highly valuable in organic
synthesis from the green chemistry point of view. In addition,
Na SO is inexpensive, easy to use and it is also considered non-
2 3
toxic reagent.
This new reaction protocol takes advantage of the reducing
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Experimental Section
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Arylboronic acids were obtained from Aldrich Chemical Co. Reagents and
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Authors acknowledge INFIQC-CONICET and Universidad
Nacional de Córdoba (UNC). This work was partly supported by
CONICET, SECyT-UNC and FONCyT. WDCG gratefully
acknowledges the receipt of a fellowship from CONICET. We also
acknowledge Dr. G. Bonetto for the technical assistance with
NMR facility.
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Keywords: green chemistry • hydroxylation • phenols • synthetic
method • water chemistry
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