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O rP gl ea na si ce &d Bo i on mo to al e dc juu l sa tr mC ha er mg i ins ts ry
Journal Name
COMMUNICATION
Conflicts of interest
DOI: 10.1039/D0OB00226G
The authors state that there are no conflicts to declare.
Aknowledgements
We acknowledge SOLEIL synchrotron for provision of
synchrotron radiation facilities (proposal ID 20140774,
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0150780, 20160782, and 20170872) in using Proxima
beamlines. M.Ku. and M. Ko. were funded by ERASMUS
European program. AP, PL and RD acknowledge support from
Région Centre Val-de-Loire, University of Orléans, CNRS and
LABEX Synorg (ANR-11-LABX-0029).
Scheme 2: Thioglycoligation of 4-chlorothiophenol using baicalin as glucuronide
donor.
Taken these 4 thiols as model acceptors, this is the first example
of using a thioligase to generate S-glucuronides bearing
aromatic aglycon moiety.
References
In addition, we also probed the ability of DtGlcA-E396Q to use a
natural glucuronide as sugar donor, namely baicalin. This
natural compound is the glucuronide of flavone baicalein, which
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In the search of original biocatalyst promoting thioligation,
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considering S-glucuronide formation)
. Moreover, baicalin, a
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as it broadens the potentiality of this approach.
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