10.1002/cctc.201700517
ChemCatChem
COMMUNICATION
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In conclusion, a strategy for ligand controlled divergent synthesis
of aldehyde and acid from aryl halides had been established.
With formic acid as the carbonyl source, a wide range of
substituted aryl halides were transformed into the corresponding
aldehydes or acid derivatives selectively in moderate to
excellent yields. Generally, small sterically hindered
monodentate alkylphosphine facilitate the formation of
aldehydes, while wide bite angle bidentate ligand promote the
formation of acid. This strategy provides a general method for
the divergent synthesis of aldehydes and carboxylic acids from
easily available aryl halides under identical reaction conditions.
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Acknowledgements
The authors thank the financial supports from NSFC (21472174,
21602201, 21602204) and Zhejiang Natural Science Fund for
Distinguished Young Scholars (LR16B020002).
Keywords: palladium catalyst • coupling reaction • formic acid •
reductive carbonylation • carboxylation
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