Journal of Fluorine Chemistry p. 341 - 351 (1991)
Update date:2022-08-11
Topics:
Suzuki, Hiroshi
Kimura, Yoshikazu
3,4-Difluorobenzonitrile has been prepared by a halogen-exchange reaction between 3,4-dichlorobenzonitrile and spraydried potassium fluoride in the presence of tetraphenylphosphonium bromide in refluxing 1,3-dimethylimidazolidine-2-one.In the fluorination reaction, 4-chloro-3-fluorobenzonitrile seems to be a key intermediate. 3,4-Difluorobenzonitrile, 2-, 3-, and 4-fluorobenzonitriles have also been produced from the corresponding chlorobenzonitrile derivatives by halogen-exchange at 290 deg C, in DMI in a pressure reactor.
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