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ChemComm
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COMMUNICATION
Journal Name
In summary, Ru(II)-catalyzed a convenient hydrogenation of
challenging primary amides and cyclic di-peptides to the
corresponding primary alcohols, and amino alcohols,
respectively is developed. The reaction proceeds under mild
hydrogen pressure, and low temperature and the
hydrogenation reaction can be scaled-up.
Kon, S. Furukawa, H. Ariga, K. Asakura, K. Yoshizawa and K.
DOI: 10.1039/D0CC04550K
Shimizu, Chem. Eur. J. 2017, 23, 14848; (n) T. Mitsudome, K.
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Conflicts of interest
5
511; (r) T. Kawano, R. Watari, Y. Kayaki and T. Ikariya,
“
There are no conflicts to declare”.
Synthesis, 2019, 51, 2542; (s) J. Chen, J. Wang and T. Tu,
Chem Asian J. 2018, 13, 2559; (t) L. A. Suàrez, Z. Culakova, D.
Balcells, W. H. Bernskoetter, O. Eisenstein, K. I. Goldberg, N.
Hazari, M. Tilset and A. Nova, ACS Catal. 2018, 8, 8751.
For selected examples of hydrogenation of amides via C–N
bond cleavage, see: (a) P. Hu, Y. Ben-David and D. Milstein,
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L. Rasu, J. M. John, E. Stephenson, R. Endean, S. Kalapugama,
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Acknowledgements
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This research work was supported by SERB, India (Grant No:
CRG/2018/002480/OC). MS thanks the UGC and GS thanks the IISER
-
Tirupati for fellowships.
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