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added NIS (0.05mmol). The mixture was stirred at
room temperature for the period of time indicated in
Table 1. Reaction progress was monitored by GC or
TLC. After completion of the reaction, the product
was isolated by rapid filtration through a short pad of
silica gel. Evaporation of the solvent under reduced
pressure gave the corresponding alcohol in good to
excellent yields (Table 1).
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In conclusion, we have established a mild, simple, and
highly selective method for deprotection of alcoholic
TBDMS ethers using a catalytic amount of NIS in meth-
anol at room temperature. The reaction is selective for
alkyl silyl ethers and the yields of product are very good
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The authors thank the Institute for Advanced Studies in
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