Organic Process Research and Development p. 1312 - 1317 (2018)
Update date:2022-08-16
Topics:
Matsumoto, Yohei
Kuriyama, Masami
Yamamoto, Kosuke
Nishida, Koyo
Onomura, Osamu
A direct metal-free approach for the production of adipic acid from cyclohexane is reported. The use of N-hydroxyphthalimide (NHPI) as a catalyst in the presence of HNO3/TFA enables the direct oxidation of cyclohexane to yield adipic acid under ambient temperature and pressure via a simple procedure. This reaction proceeds through an initial oxidation of cyclohexane to cyclohexanone oxime and cyclohexanone followed by a second oxidation of these intermediates to adipic acid. NHPI plays a crucial role in both oxidation steps to achieve a high yield and selectivity for adipic acid.
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