Journal of Medicinal Chemistry p. 6609 - 6628 (2018)
Update date:2022-08-16
Topics:
Tajabadi, Fatemeh Mazraati
Pouwer, Rebecca H.
Liu, Miaomiao
Dashti, Yousef
Campitelli, Marc R.
Murtaza, Mariyam
Mellick, George D.
Wood, Stephen A.
Jenkins, Ian D.
Quinn, Ronald J.
A chemoinformatic method was developed to extract nonflat scaffolds embedded in natural products within the Dictionary of Natural Products (DNP). The cedrane scaffold was then chosen as an example of a nonflat scaffold that directs substituents in three-dimensional (3D) space. A cedrane scaffold that has three orthogonal handles to allow generation of 1D, 2D, and 3D libraries was synthesized on a large scale. These libraries would cover more than 50% of the natural diversity of natural products with an embedded cedrane scaffold. Synthesis of three focused natural product-like libraries based on the 3D cedrane scaffold was achieved. A phenotypic assay was used to test the biological profile of synthesized compounds against normal and Parkinson's patient-derived cells. The cytological profiles of the synthesized analogues based on the cedrane scaffold revealed that this 3D scaffold, prevalidated by nature, can interact with biological systems as it displayed various effects against normal and Parkinson's patient-derived cell lines.
View MoreHangzhou Yanshan Chemical Co.,Ltd.
Contact:86-571- 87698076
Address:Room 1001, #1 Building, Zhongtian MCC, No.2 Youzhinong, Wenyi West Road, Xihu District, Hangzhou, China
Shanghai WinTide BioTechnology Co.,Ltd
Contact:86-21-37100630
Address:No. 908 Yunhe Road, Fengxian district, Shanghai
Beijing Green Guardee Technology CO,.LTD
Contact:+86-10-69706062
Address:F2 BLdj,5 No.37 Chaoqian Road
Contact:0086-573-82201031
Address:Jiaxing Industrial Park, Daqiao Town, Jiaxing
Qingdao Kylin Trading Co., Ltd.
Contact:0086-532-68979884/58972912/68972263/65/88171519
Address:Room 2308,A building International Trade Center No.230 Changjiang Middle Road of Qingdao Economic Development Zone,Shandong,China.
Doi:10.1021/ma035516s
(2004)Doi:10.1016/j.poly.2013.06.022
(2013)Doi:10.1021/ja2033525
(2011)Doi:10.1002/aoc.4076
(2018)Doi:10.1021/ja00741a026
(1971)Doi:10.1021/acs.oprd.5b00256
(2015)