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Acknowledgements This work was supported by the NSF under the CCI Center for
Selective C–H Functionalization (CHE-1205646) and under CHE-1212767, and by BP
under the XC2 initiative. We thank the Novartis Institutes for Biomedical Research
Incorporated for the donation of samples to the CCHF. D. Morton is thanked for a
donation of thenalidine. A.A.T. is grateful to the Resnick Sustainability Institute at
Caltech and to Dow Chemical for a predoctoral fellowship, and to NSERC for a PGS D
fellowship. The Shanghai Institute of Organic Chemistry (SIOC) and S.-L. You are
thanked for a postdoctoral fellowship to W.-B.L. We thank S. Virgil and the Caltech
Center for Catalysis and Chemical Synthesis for access to analytical equipment.
D. Vandervelde is acknowledged for assistance with NMR interpretation. N. Dalleska is
thanked for assistance with ICP-MS trace metal analysis. M. Shahgoli and N. Torian are
acknowledged for assistance with high-resolution mass spectrometry.
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Author Contributions A.A.T., W.-B.L. and K.N.B. developed the reactions, performed the
experiments and analysed data. A.F. analysed data. A.A.T and R.H.G. had the idea for
and directed the investigations with W.-B.L. and B.M.S. A.A.T. and W.-B.L. prepared the
manuscript with contributions from all authors. All authors contributed to discussions.
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dehydrogenative Si–O coupling: reactivity pattern and mechanism of an
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