Tetrahedron Asymmetry p. 2863 - 2870 (1999)
Update date:2022-08-16
Topics:
Lutje Spelberg, Jeffrey H.
Van Hylckama Vlieg, Johan E. T.
Bosma, Tjibbe
Kellogg, Richard M.
Janssen, Dick B.
The recombinant halohydrin dehalogenase from Agrobacterium radiobacter AD1 was used to obtain enantiomerically pure halohydrins and epoxides by kinetic resolution. By adding an excess of the recombinant epoxide hydrolase from the same organism the reversible conversion was drawn to completion. Halohydrins such as (S)-2,3-dichloro-1-propanol (E>100) and (S)-2-chloro-1-phenylethanol (E=73) were obtained with an enantiomeric excess of higher than 99%. This is a novel biocatalytic route for obtaining enantiomerically pure aromatic halohydrins and epoxides.
View MoreNANCHANG QINZHI SCI&TEC.CO.,LTD
Contact:+86-13687004106
Address:Hero South Road,Hero Zone,Nanchang,Jiangxi,China
Anhui Gusheng Import&Export CO.,LTD
Contact:86-551-63662296
Address:Jinzhai Road NO.162 ,hefei, china
Jiangxi Lixin Pharmaceutical Co.,Ltd.
Contact:0798-8337222; 18979813215
Address:Jiangxi City, Jindezheng Province
Contact:86-516-66656369
Address:The west road of Huaihai, Xuzhou, China
Shenzhen JYMed Technology Co.,Ltd.
website:http://www.jymedtech.com
Contact:+86-755-26612112
Address:RM1-105, Shenzhen Bio-incubator Base, 10 Gaoxin C Avc 1st, Nanshan District, Shenzhen, GD, China, 518057
Doi:10.1021/ja01549a089
(1958)Doi:10.1002/anie.202102719
(2021)Doi:10.1016/0031-9422(72)80101-8
(1972)Doi:10.1021/j100261a013
(1985)Doi:10.1080/00397919708006783
(1997)Doi:10.1016/S0040-4039(01)97838-4
()