9
26ꢀꢀꢀꢀꢁꢀG. Rahimzadeh et al.: Improvement of the Van Leusen reaction
O
+
N
C
Tos
_
Tos
Ar
Et N
+
N
3
+
N
Ar
H
N
_
C
_
C
Tos
Tos
_
+
(2)
_
Ar
-
Et NH
O
O
3
1
4
5
6
Tos
Tos
_
+
Et NH
Et N
N
3
N
3
N
-
Et N
H
Ar
3
Ar
Ar
O
7
O
8
O
3
Scheme 1:ꢀPlausible reaction mechanism.
[
11] S. Li, R. Chen, X. Liu, L. Pan, L. Xia, X. Chen, Synlett 2012, 23, 1985.
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4
Supporting information
[
2
The general procedure for the preparation of oxazoles 3, [13] A. M. Van Leusen, B. E. Hoogenboom, H. Siderius, Tetrahedron
1
13
their H and C NMR spectroscopic data, as well as copies
of these spectra are given as Supporting Information,
which is available online (DOI: 10.1515/znb-2017-0005).
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[
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[
Acknowledgments: This study was supported by the
Research Council of Tehran University of Medicinal Sci- [17] B. Wu, J. Wen, J. Zhang, J. Li, Y.-Z. Xiang, X.-Q. Yu, Synlett
2
009, 500.
ences and the Iran National Science Foundation.
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