Organic Letters p. 331 - 334 (2020)
Update date:2022-08-11
Topics:
Cheng, Hong-Gang
Pu, Maoping
Kundu, Gourab
Schoenebeck, Franziska
We herein disclose the use of tetramethylammonium fluoride (TMAF) as a direct and selective methylating agent of a variety of amides, indoles, pyrroles, imidazoles, alcohols, and thiols. The method is characterized by operational simplicity, wide scope, and ease of purification. Our computational studies suggest a concerted methylation-deprotonation as the preferred reaction pathway.
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