Asymmetric bioreduction of p-haloacetophenones 327
concentration of substrates (1 mM). In our work,
-haloacetophenones were asymetrically reduced by
Declaration of interest: The authors report no
declarations of interest.The authors alone are respon-
sible for the content and writing of the paper.
This research was financially supported by
Scientific Research & Technology Development
Project of Guangxi Zhuang Autonomous Region
(No: 1099061-2).
4
Mucor sp. CG10, followed the Prelog rule, at a rela-
tively high concentration (10–30 mM). As Table I
shows, when the substrates concentration was
increased to 20 mM (glucose 20 g/L), satisfactory
results were obtained, with conversions of 1a–1d
(
Ͼ93%) and ee of 2a–2d (Ͼ92%). When the con-
centration of 1a was further increased up to 30 mM
glucose 20 g/L), the reaction conversion achieved
7% and ee 92%, indicating the potential for indus-
(
9
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Acknowledgements
None.