ENANTIOSEPARATION OF RACEMIC MIXTURES BASED ON SOLVENT SUBLATION
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Fig. 8. Influence of the initial concentration of sodium lauryl sulfate (SDS)
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(L-DBTA), and di-(2-ethylhexyl) phosphoric acid (D2EHPA): 1.67 mg/ml,
0.11 g/l, and 0.91 mol/l, respectively. pH 7.0 and reflux time of 4 h. (b) Initial
concentration of racemic tryptophan, L-DBTA, and D2EHPA: 1.40 mg/ml,
0.20 g/l, and 1.51 mol/l, respectively. pH 5.80 and reflux time of 4 h.
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influence the results of enantioseparation, were investigated.
The results showed that the enantioselectivity was enhanced
compared with the usual two-phase (O/W) recognition chiral
extraction. Under the optimal operational conditions, the
enantiomeric excess and enantioselectivity were 60.08% and
5.58 for Oflx and 65.09% and 6.31 for Trp, respectively. The
yields of D-enatiomer and L-enantiomer were 34.23% and
8.54% for Oflx and 18.59% and 3.93% for Trp, respectively.
What’s more, this technique, with advantages of simultaneous
foam adsorption and solvent extraction, very low expenditure
of organic solvent, very little amount of chiral selectors, and
easy realization of multistage operation, would have a consider-
able number of potential applications in chiral separation.
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Chirality DOI 10.1002/chir