ALI ET AL.
7
3,4,6,26,37-39
is a good chiral selector.
Teiocoplanin has 23 chi-
ORCID
ral centers with three cavities. The hydrogen donners and
acceptors sites are readily available close to the ring struc-
ture. The molecule also has a hydrophobic acyl site chain
attached to a 2‐amino‐2‐deoxy‐β‐D‐glucopyranosyl moi-
ety, which activates its surface and enables the formation
of micellar aggregates. All these features made this mole-
cule chiral and highly stereospecific in nature. Teicoplanin
molecule provides the stereoselective hydrogen bondings,
inclusion complexation, diploe interactions, steric interac-
tions, and anionic and cationic bondings to the enantio-
mers of quinolones. The enantiomers of quinolones have
oxygen and nitrogen atoms, which interacted with
teicoplanin via hydrogen bondings. Therefore, hydrogen
bonding are the major controlling factors. However, the
other forces as mentioned above are also playing crucial
role in the chiral recognition of the enantiomers of the
reported quinolones. Finally, the stereomers of these quin-
olones are fixed stereospecifically at various extents. As per
the modeling results, R‐enantiomers interacted strongly in
comparison to S‐enantiomers. The flow of mobile phase is
pushing these enantiomers out of the column. As a result
of these competitive interactions, S‐enantiomers eluted
first followed by R‐enantiomers.
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The authors are thankful to Department of Science and
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Research (RFBR), Russia, (Grant No. 16‐53‐45003) for
funding this work.
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CONFLICT OF INTEREST
The authors have no conflict of interest.