Bulletin of the Chemical Society of Japan p. 3531 - 3538 (1988)
Update date:2022-08-10
Topics:
Akiyama, Takeo
Kato, Kohji
Kajitani, Masatsugu
Sakaguchi, Yoshio
Nakamura, Junko
et al.
The photochemical introduction of trifluoromethyl group with CF3Br in aromatic and heteroaromatic rings was investigated for 9 compounds.Naphthalene, anthracene, anisole, N,N-dimethylaniline, ferrocene, benzothiophene, isoquinoline, and N-methylpyrrole gave trifluoromethylated products in 6.5-100percent yields.In one step from uracil, a pharmacologically important 5-trifluoromethyluracil can be synthesized by this method in 11percent yield.Based on the mechanistic study carried out for the naphthalene-CF3Br-CH3CN system, the reaction is found to proceed via the electron transfer from an excited singlet state of naphthalene to CF3Br.
View MoreContact:86-551-63540590
Address:No 1388 Furong Rd., Hefei, Anhui, China
Hebei Tianxiang Biological & Pharmaceutical Co., Ltd
Contact:86-0312-6615158
Address:No 42 fazhan street qingyuan county
Hubei Sky Lake Chemical Co., Ltd.
Contact:+86-27-87385545
Address:Te-2, Xijiao Chemical Park, Yuekou Town, Tianmen, Hubei, China.
Sichuan Sangao Biochemical Co., Ltd
Contact:+86-28-84874233
Address:19F, Bldg.2, Shudu Center, Tianfu 2nd St., Hi-tech zone, Chengdu 610041, Sichuan Province, China.
Shanghai Dano Pharmaceutical Co.,Ld.
Contact:+86-592-6266840
Address:Building 1 Room 512, 720 Cailun Rd, Zhangjiang High-Tech Park, Shanghai 201203, China
Doi:10.1016/S0025-5408(01)00560-8
(2001)Doi:10.1107/S0567740874003712
(1974)Doi:10.1371/journal.pone.0168739
(2016)Doi:10.1016/j.tetlet.2017.05.085
(2017)Doi:10.1021/jo00172a003
(1983)Doi:10.1039/c4ra11128a
(2014)