Bioscience, Biotechnology and Biochemistry p. 1664 - 1666 (1999)
Update date:2022-08-16
Topics:
Fukuyama, Yasuaki
Matoishi, Kaori
Iwasaki, Masakazu
Takizawa, Eiji
Miyazaki, Mamoru
Ohta, Hiromichi
Hanzawa, Satoshi
Kakidani, Hitoshi
Sugai, Takeshi
A preparative-scale asymmetric synthesis of (R)-α-fluorophenylacetic acid, a useful chiral derivatizing reagent, is described. Starting from ethyl α-bromophenylacetate, α-fluorophenylmalonic acid dipotassium salt was prepared in three steps (54% yield), including nucleophilic substitution by the fluoride ion as the keystep. Both the purified form and crude preparation of arylmalonate decarboxylase in E. coli worked well on this substrate, and (R)-α-flurophenylacetic acid (>99% e.e.) was prepared in a quantitative yield.
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Doi:10.1039/jr9590003378
(1959)Doi:10.1007/BF00601474
(1966)Doi:10.1021/j100864a051
(1967)Doi:10.1016/S0009-3084(02)00052-X
(2002)Doi:10.1016/j.tet.2016.03.064
(2016)Doi:10.1016/j.tetlet.2008.04.077
(2008)