Chemical Science
Edge Article
for further applications. Moreover, this technology offers
avenues to further probe the mechanisms that lead to enhanced
efficacy of polymer and nanomaterial therapeutics.
H. M. Janssen, A. H. A. M. van Onzen, P. J. Hudson and
M. S. Robillard, Nat. Commun., 2018, 9, 1484.
10 R. M. Versteegen, R. Rossin, W. ten Hoeve, H. M. Janssen
and M. S. Robillard, Angew. Chem., Int. Ed., 2013, 52,
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Ethical statement
11 J. M. Mejia Oneto, I. Khan, L. Seebald and M. Royzen, ACS
Cent. Sci., 2016, 2, 476–482.
All animal experiments were approved by the University of
Queensland's Animal Ethics Committee (AEC530/15) and con- 12 S. S. Kelkar and T. M. Reineke, Bioconjugate Chem., 2011, 22,
formed to the Animal Care and Protection Act Qld and the Code 1879–1903.
of Practice for the care and use of animals for scientic 13 J. Shi, P. W. Kantoff, R. Wooster and O. C. Farokhzad, Nat.
purposes.
Rev. Cancer, 2016, 17, 20.
14 B. Sumer and J. Gao, Nanomedicine, 2008, 3, 137–140.
15 M. Azoulay, G. Tuffin, W. Sallem and J. C. Florent, Bioorg.
Med. Chem. Lett., 2006, 16, 3147–3149.
Conflicts of interest
There are no conicts to declare.
16 S. S. Matikonda, D. L. Orsi, V. Staudacher, I. A. Jenkins,
F. Fiedler, J. Chen and A. B. Gamble, Chem. Sci., 2015, 6,
1212–1218.
17 S. S. Matikonda, J. M. Fairhall, F. Fiedler, S. Sanhajariya,
R. A. J. Tucker, S. Hook, A. L. Garden and A. B. Gamble,
Bioconjugate Chem., 2018, 29, 324–334.
Acknowledgements
The authors acknowledge the facilities, and the scientic and
technical assistance of the National Imaging Facility at the
Centre for Advanced Imaging, University of Queensland. 18 C. S. McKay and M. Finn, Chem. Biol., 2014, 21, 1075–1101.
Funding for this research is acknowledged from the National 19 P. Polakis, Pharmacol. Rev., 2016, 68, 3–19.
Health and Medical Research Council (APP1099321 and 20 X. Fan, Y. Ge, F. Lin, Y. Yang, G. Zhang, W. S. Ngai, Z. Lin,
APP1148582 (K. J. T.); APP1054569 (C. A. B.)) and the Australian
Research Council (LP150100703 (K. J. T.)). This work was per-
S. Zheng, J. Wang, J. Zhao, J. Li and P. R. Chen, Angew.
Chem., Int. Ed. Engl., 2016, 55, 14046–14050.
formed in part at the Queensland node of the Australian 21 J. C. T. Carlson, H. Mikula and R. Weissleder, J. Am. Chem.
National Fabrication Facility (ANFF), a company established
Soc., 2018, 140, 3603–3612.
under the National Collaborative Research Infrastructure 22 R. Rossin, T. Lappchen, S. M. van den Bosch, R. Laforest and
Strategy to provide nano- and microfabrication facilities for M. S. Robillard, J. Nucl. Med., 2013, 54, 1989–1995.
Australia's researchers. This research was conducted and fun- 23 R. Membreno, B. E. Cook, K. Fung, J. S. Lewis and
ded by the ARC Centre of Excellence in Convergent Bio-Nano B. M. Zeglis, Mol. Pharm., 2018, 15, 1729–1734.
Science and Technology (CE140100036) and in part by the ARC 24 R. Boellaard, J. Nucl. Med., 2009, 50(suppl 1), 11s–20s.
Training Centre for Innovation in Biomedical Imaging Tech- 25 B. Bai, J. Bading and P. S. Conti, Theranostics, 2013, 3, 787.
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26 M. Wang, D. Svatunek, K. Rohlng, Y. Liu, H. Wang, B. Giglio,
H. Yuan, Z. Wu, Z. Li and J. Fox, Theranostics, 2016, 6, 887.
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