ACS Catalysis
Research Article
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Toste, F. D. A Supramolecular Approach to Combining Enzymatic
and Transition Metal Catalysis. Nat. Chem. 2013, 5, 100−103.
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Two-Step Cascade Reactions. J. Am. Chem. Soc. 2017, 139, 6090−
6093.
In summary, this contribution introduces micellar-based
compartmentalized nanoreactors as supports for incompatible
oxidation and reduction reactions. The SCMs provided
indispensable catalyst site isolation and enhanced catalyst
reactivity. The one-pot redox-driven deracemizations using our
catalyst-functionalized SCMs yielded outstanding conversions
and enantioselectivities for various substrates. Our nano-
reactors can be reused in a continuous manner while
maintaining high reactivities. Future research in our group
will focus on preparing advanced tunable multicompartmen-
talized SCM nanoreactors to regulate the order of multistep
redox-driven transformations and to construct useful synthetic
building blocks.
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(10) Chi, Y.; Scroggins, S. T.; Frechet, J. M. J. One-Pot Multi-
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Star Polymers with Highly Branched Non-Interpenetrating Catalytic
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(11) Helms, B.; Guillaudeu, S. J.; Xie, Y.; McMurdo, M.; Hawker, C.
J.; Frechet, J. M. One-pot Reaction Cascades Using Star Polymers
with Core-confined Catalysts. Angew. Chem., Int. Ed. 2005, 44, 6384−
6387.
(12) Xiong, L.; Zhang, H.; Zhong, A.; He, Z.; Huang, K. Acid- and
base-functionalized Core-confined Bottlebrush Copolymer Catalysts
for One-pot Cascade Reactions. Chem. Commun. 2014, 50, 14778−
14781.
(13) Runge, M. B.; Mwangi, M. T.; Miller, A. L., 2nd; Perring, M.;
Bowden, N. B. Cascade Reactions Using LiAlH4 and Grignard
Reagents in the Presence of Water. Angew. Chem., Int. Ed. 2008, 47,
935−939.
(14) Yang, Y.; Liu, X.; Li, X.; Zhao, J.; Bai, S.; Liu, J.; Yang, Q. A
Yolk-shell Nanoreactor with a Basic Core and an Acidic Shell for
Cascade Reactions. Angew. Chem., Int. Ed. 2012, 51, 9164−9168.
(15) Tan, H.; Guo, S.; Dinh, N.-D.; Luo, R.; Jin, L.; Chen, C.-H.
Heterogeneous Multi-compartmental Hydrogel Particles as Synthetic
Cells for Incompatible Tandem Reactions. Nat. Commun. 2017, 8,
663.
ASSOCIATED CONTENT
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S
* Supporting Information
The Supporting Information is available free of charge on the
Synthetic procedures, experimental details of micelle-
supported catalytic tests, DLS details, ICP-MS, and cryo-
AUTHOR INFORMATION
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Corresponding Author
ORCID
(16) Fukuzumi, S.; Lee, Y.-M.; Nam, W. Immobilization of
Molecular Catalysts for Enhanced Redox Catalysis. ChemCatChem
2018, 10, 1686−1702.
(17) Li, F.; Fan, K.; Xu, B.; Gabrielsson, E.; Daniel, Q.; Li, L.; Sun,
L. Organic Dye-Sensitized Tandem Photoelectrochemical Cell for
Light Driven Total Water Splitting. J. Am. Chem. Soc. 2015, 137,
9153−9159.
(18) You, B.; Liu, X.; Jiang, N.; Sun, Y. A General Strategy for
Decoupled Hydrogen Production from Water Splitting by Integrating
Oxidative Biomass Valorization. J. Am. Chem. Soc. 2016, 138, 13639−
13646.
Notes
The authors declare no competing financial interest.
ACKNOWLEDGMENTS
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Funding provided by the U.S. Department of Energy, Office of
Basic Energy Sciences, through Catalysis Science Contract DE-
FG02-03ER15459, is gratefully acknowledged. We thank
Kristen Dancel-Manning from the OCS Microscopy Core at
New York University Langone Medical Center for obtaining
the cryo-TEM images.
̈
(19) Sato, H.; Hummel, W.; Groger, H. Cooperative Catalysis of
Noncompatible Catalysts through Compartmentalization: Wacker
Oxidation and Enzymatic Reduction in a One-Pot Process in Aqueous
Media. Angew. Chem., Int. Ed. 2015, 54, 4488−4492.
(20) Womble, C. T.; Kuepfert, M.; Weck, M. Multicompartment
Polymeric Nanoreactors for Non-Orthogonal Cascade Catalysis.
Macromol. Rapid Commun. 2019, 40, 1800580.
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