Organic Letters
Letter
a
Scheme 4. Substrate Scope for Ester of Ciprofloxacin
ACKNOWLEDGMENTS
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We are thankful to the Director, CSIR-IHBT, Palampur (H.P.),
for the necessary infrastructure. We are also thankful to Mr.
Digvijay Singh Naruka for performing MicroCal Auto-iTC200
at CSIR-IMTECH Chandigarh. M.S.T. is thankful to the
University Grants Commission, New Delhi, for a senior
research fellowship. S.K.M. is thankful to the SERB, Govern-
ment of India, for an early career research award (ECR/2016/
000134). CSIR-IHBT Communication No. 4205.
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Reaction conditions: aldehyde (1, 1.3 mmol), ciprofloxacin derivative
(4, 1 mmol), L2 (20 mol %), HCOOH (2 equiv), MeCN (4 mL), and
molecular sieves at 100 °C for 5 h. Isolated yield.
a
Scheme 5. Substrate Scope for Ciprofloxacin
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a
Reaction conditions: aldehyde (1, 1.3 mmol), ciprofloxacin (6, 1
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molecular sieves at 100 °C for 5 h. Isolated yield.
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ASSOCIATED CONTENT
* Supporting Information
The Supporting Information is available free of charge on the
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Experimental details, data, and spectra (PDF)
AUTHOR INFORMATION
Corresponding Author
(15) Wang, S.; Jia, X. D.; Liu, M. L.; Lu, Y.; Guo, H. Y. Bioorg. Med.
Chem. Lett. 2012, 22, 5971.
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ORCID
Notes
The authors declare no competing financial interest.
§Deceased.
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Org. Lett. XXXX, XXX, XXX−XXX