2
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Synlett
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Letter
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12) were inert under the reaction conditions.
In conclusion, the reaction of sulfides 1 with NaOCl·5H O
2
(1.1 equiv) in aqueous acetonitrile produces the corre-
27.
sponding sulfoxides 2 selectively in high yields. This meth-
(
4) For a review, see: Kaczorowska, K.; Kolarska, Z.; Mitka, K.;
od is experimentally simple, and NaOCl·5H O is now com-
2
Kowalski, P. Tetrahedron 2005, 61, 8315.
mercially available and inexpensive. Moreover, in the oxida-
tion of sulfides to sulfoxides, the addition of the correct
amount of oxidants is important to prevent overoxidation
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2
it ideal for this purpose. This procedure provides a superior
method for the preparation of industrially and biologically
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1559. (e) Rostami, A.; Atashkar, B. J. Mol. Catal. A: Chem. 2015,
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(
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(
11) NaOCl·5H O is commercially available from Wako Pure Chemi-
2
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©
Georg Thieme Verlag Stuttgart · New York — Synlett 2015, 26, 2547–2552