10.1002/asia.202000065
Chemistry - An Asian Journal
COMMUNICATION
mixed solution was introduced into Columns II at a total flow rate of 0.10
mL/min. During the reactions, Column I was heated at 75 °C and
Columns II-1 and II-2 were cooled at 0 °C. The resulting solution from
Column II-2 and acetone were introduced into the pre-column at flow
rates of 0.10 mL/min and 0.033 mL/min, respectively. The mixed solution
(total flow rate 0.133 mL/min) and gaseous hydrogen (3.0 mL/min) were
introduced into Column III on the top of the column. During the reactions,
Column III was heated at 100 °C. After stabilization, several fractions
were collected to check the progress of the reaction. To analyze
composition, the collected solution was evaporated under vacuum and
then purified by preparative TLC (ethyl acetate) to determine the yield.
The enantioselectivity of the obtained product was determined by chiral
HPLC analysis.
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Acknowledgments
This work was partially supported by a Grant-in-Aid for Science
Research from the Japan Society for the Promotion of Science
(JSPS), the Global COE Program, the University of Tokyo, the
Ministry of Education, Culture, Sports, Science and Technology
(MEXT), Japan, the Japan Science and Technology Agency
(JST), and the Japan Agency for Medical Research and
Development (AMED).
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Keywords: Sequential flow reaction • Heterogeneous catalyst •
Hydrogenation • Trickle-bed reactor • Baclofen
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