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cional de Investigaciones Cient ´ı ficas y T e´ cnicas (CONICET),
Agencia Nacional de Promoci o´ n Cient ´ı fica y Tecnol o´ gica,
Fundaci o´ n Prats and Universidad Nacional de Rosario from
Argentina is gratefully acknowledged. L.M. thanks CONICET
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(23) Typical procedure for the solid-phase synthesis of multicyclic
ꢀ-lactam derivatives: The immobilized 4-hydroxyphenoxy-
acetic acid (5) (183.6 mg, 0.17 mmol) was suspended in
anhydrous chloroform (2 mL), and a solution of 6,7-dimethoxy-
1-phenyl-3,4-dihydroisoquinoline 12b (227.22 mg, 0.85 mmol,
5 equiv) in chloroform and triethylamine (0.14 mL, 1.02
mmol, 6 equiv) were added under a nitrogen atmosphere. After
few minutes, Mukaiyama’s reagent (8) (130.3 mg, 0.51 mmol,
3 equiv) was added, and the suspension was refluxed for 2 h.
(
(