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COMMUNICATION
Journal Name
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Scheme 5 Plausible mechanism.
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2
To summarize, we developed a mild method for synthesis of
unsymmetrical ketones via acylation of benzylic C-H bond. The
method uses the combination of a photoactive benzophenone
derivative and a nickel complex, in a dual catalytic reaction. 4-
benzoylphenyl acetate was chosen as the photocatalyst after
careful optimization. A broad range of aromatic and aliphatic
acid chlorides could be successfully employed for the acylation
of toluene. Additionally, anhydrides worked well as acylating
agent under our conditions. Apart from toluene, other
substituted methylbenzenes also underwent acylation at the
benzylic position providing a valuable and efficient alternative
to classical ketone synthesis using acylations.
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0
, 4094-4098; (d) R. A. Swyka, W. G. Shuler, B. J. Spinello, W.
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,
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Molander, ACS Catal., 2017, 7, 2563-2575; (d) D. C. Fabry and
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Conflicts of interest
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382; (e) S. O. Badir, A. Dumoulin, J. K. Matsui and G. A.
There are no conflicts to declare.
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