N,N0-Disubstituted Ureas/Thioureas
1793
and N,N0-bis-(3,4-methylenedioxyphenyl) urea enhance adventitious root
formation in apple rootstock M26 (Malus pumila Mill). Plant Sci. 2001, 160,
1055–1065.
2. Boden, P.; Eden, J. M.; Hodgson, J.; Horwell, D. C.; Pritchard, M. C.; Raphy, J.;
Suman-Chauhan, N. The development of a novel series of non-peptide tachykinin
NK3 receptor selective antagonists. Bioorg. Med. Chem. Lett. 1995, 5, 1773–1778,
and references cited therein.
3. Wieland, H. A.; Engel, W.; Eberlein, W.; Rudolf, K.; Doods, H. N. Subtype selec-
tivity of the novel nonpeptide neuropeptide Y Y1 receptor. Br. J. Pharmacol. 1998,
125, 549–555.
4. (a) Hegarty, A. F.; Drennan, L. J, In Comprehensive Organic Functional Group
Transformations; Gilchrist, T. L., Ed.; Pergamon Press: Oxford, 1995; Vol. 6,
pp. 499–510; (b) March, J. Advanced Organic Chemistry; John Wiley & sons.;
IV Ed.: New York, 1992, p. 424; (c) Cavalieri, L. F.; Blair, V. E.; Brown, G. B.
The synthesis of uric acid containing isotopic nitrogen. J. Am. Chem. Soc. 1948,
70, 1270–1242.
5. Sawai, H.; Takizawa, T. Oxidative a-addition of isonitrile by use of mercuric salts
synthesis of urea and urethane. Tetrahedron Lett. 1972, 13, 4263–4266.
6. Schreiber, J.; Witkop, B. The reaction of cyanogen bromide with mono- and
diamino acids. J. Am. Chem. Soc. 1964, 86, 2441–2445.
7. Katritzky, A. R.; Kirichenko, N.; Rogovoy, B. V. Synthesis of mono- and N,N-dis-
ubstituted ureas. ARKIVOC 2003, viii, 8–14.
8. (a) March, J. Advanced Organic Chemistry; Wiley: New York, 1985; pp. 370–375;
(b) Knolker, H. J.; Braxmeier, T.; Schlechtingen, G. A novel method for the
synthesis of isocyanates inder mild conditions. Angew. Chem. Int. Ed. Engl. 1995,
34, 2497–2500; (c) Shriener, R. L.; Horne, W. H.; Cox, R. F. Organic Synthesis;
Wiley: New York, 1994, Vol. 2; 453.
9. (a) Bigi, F.; Maggi, R.; Sartori, G.. Selected syntheses of ureas through phosgene
substitutes. Green Chem. 20002, 140–148; (b) Flyes, T. M.; James, T. D.;
Pryhitka, A.; Zojsji, M. Assembly of ion channel mimics from a modular
construction set. J. Org. Chem. 1993, 58, 7456–7468.
10. Liu, Q.; Leudtke, N. W.; Tor, Y. A simple conversion of amines into mono-
substituted ureas in organic and aqueous solvents. Tetrahedron Lett., 2001, 40,
1445–1447.
11. Mojtahedi, M. M.; Saidi, M. R.; Bolourtchian, M. A novel method for the synthesis
of disubstituted urea and thioureas under microwave irradition. J. Chem. Res.,
Synop. 1999, 710–711.
.
12. Zheng, L.; Wang, Z. Y.; Zhu, W.; Xing, Y. L.; Zhao, Y. L. CeCl3 7H2O-KI-
catalyzed, environmentally friendly synthesis of N,N-disubstituted ureas in water
under microwave irradiation. Synth.Commun. 2005, 35, 2325–2331, and refer-
ences cited therein.
13. Ranu, B. C.; Dey, S. S.; Bag, S. A simple and green procedure for the synthesis of
symmetrical N,N-disubstituted thioureas on the surface of alumina under
microwave irradiation. ARKIVOC 2003, (ix), 14–20.
14. Myint, Y. Y.; Pasha, M. A. Regioselective synthesis of (a-iodoacetates from
alkenes/ammonium acetate/I2 by Woodward’s reaction. Synth. Commun. 2004,
34, 4477–4482.
15. Lancaster 2002–3: Research Chemicals; Lancaster Synthesis Ltd, Lancashire,
England, 2003; pp. 785–798.
16. Dictionary of Organic Compounds, 5th ed., 4th supplement; Chapman and Hall:
New York, 1986; B-01660, B-40114, D-07817, and D-08201.