Synthetic Communications p. 1561 - 1568 (1993)
Update date:2022-08-17
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A simple metyod for the direct formylation of amines using cyanomethyl formate is described. The formylation succeeds in moderate to high yields under mild and neutral conditions. Thus, formamides 2a-f, 2i-m are obtained at room temperature. A chemoselective N-formylation is achieved in the case of ethanolamine. The formylation of nitroanilines and the O-formylation of alcohols only succeeds in the presence of a catalytic amount of imidazole leading to 2g,h and 3a-e, respectively.
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(1960)Doi:10.1055/s-1976-24179
(1976)Doi:10.1021/acs.oprd.9b00245
(2019)Doi:10.1021/cm301351j
(2012)Doi:10.1177/107110070202300704
(1951)Doi:10.1002/cjce.5450790410
(1893)