A Highly Efficient Method for the Preparation of 3,4-Dimethylbenzaldehyde
for the chloromethylation of o-xylene. Another noteworthy
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point in our study was that we managed to develop a novel and
efficient procedure for the preparation of 3 from 2 via an
oxidation with sodium nitrate and acetic acid catalyzed by
PEG-600 in aqueous media under PTC conditions. Compared
with other oxidation procedures [35-42], this procedure not
only enhanced the yield, but also had the merits of being
economical, convenient and eco-safe. The good yields
obtained in all cases, makes this oxidation procedure very
attractive.
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In conclusion, we have developed an excellent procedure
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in an 82.5% total yield. Judging from the conditions employed,
this method has great prospects for industrial applications.
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ACKNOWLEDGEMENTS
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We thank the Ministry of Education of the Republic of
China and Natural Science Foundation of Jiangsu Province for
their support of this research.
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