Edge Article
Chemical Science
mechanism, as well as modication of the catalyst to increase 10 S. Zhang, H. Xu, C. Lou, A. M. Senan, Z. Chen and G. Yin, Eur.
productivity (e.g., by minimizing product inhibition) are
J. Org. Chem., 2017, 2017, 1870–1875.
ongoing in our laboratory.
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D. Morales-Morales, Pincer Compounds: Chemistry and
Applications, Elsevier, 2018.
Conflicts of interest
There are no conicts to declare.
13 (a) C. Gunanathan and D. Milstein, Chem. Rev., 2014, 114,
12024–12087; (b) J. R. Khusnutdinova and D. Milstein,
Angew. Chem., Int. Ed., 2015, 54, 12236–12273; (c) H. Li,
T. P. Gonçalves, D. Lupp and K.-W. Huang, ACS Catal.,
2019, 9, 1619–1629; (d) J. I. van der Vlugt, in Pincer
Compounds: Chemistry and Applications, ed. D. Morales-
Morales, Elsevier, 2018, pp. 599–621.
14 (a) C. A. Huff, J. W. Kampf and M. S. Sanford,
Organometallics, 2012, 31, 4643–4645; (b) M. Vogt,
M. Gargir, M. A. Iron, Y. Diskin-Posner, Y. Ben-David and
D. Milstein, Chem.–Eur. J., 2012, 18, 9194–9197; (c)
M. Feller, U. Gellrich, A. Anaby, Y. Diskin-Posner and
D. Milstein, J. Am. Chem. Soc., 2016, 138, 6445–6454; (d)
M. Feller, E. Ben-Ari, Y. Diskin-Posner and D. Milstein, J.
Coord. Chem., 2018, 71, 1679–1689.
Acknowledgements
Financial support from the Netherlands Organisation for
Scientic Research (NWO) (VIDI grant to EO) and the China
Scholarship Council (grant to BG) is gratefully acknowledged.
We would like to thank the Center for Information Technology
of the University of Groningen for their support and for
providing access to the Peregrine high performance computing
cluster.
Notes and references
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