Chemistry - A European Journal
10.1002/chem.201904688
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glycosylamine ligation. The high chemoselectivity of the N-glycopeptide formation
provides an alternative to the tedious protecting group manipulations of protected full-
length peptides. Furthermore, we discovered a new thioacid-mediated site-selective
and highly efficient peptide bond cleavage reaction. These findings give interesting
new insights into the chemistry and application of peptide thioacids leading to new
perspectives in peptide chemistry.
Acknowledgements
This work was supported by the Deutsche Forschungsgemeinschaft (SPP 1623).
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Keywords: glycopeptides, solid-phase peptide synthesis, thioacids, ligation
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