Dyes and Pigments p. 262 - 274 (2018)
Update date:2022-08-30
Topics:
Dejouy, Garance
Laly, Myriam
Valverde, Ibai E.
Romieu, Anthony
The first synthesis of sulfone-pyronin and sulfone-rosamine dyes bearing optically tunable primary amino groups (acting as fluorogenic centers) is presented. Sulfone analogs of xanthene-based fluorophores have recently been highlighted as a new class of near-infrared (NIR) fluorescent dyes (Liu et al. ACS Appl Mater Interfaces 2016; 8(35):22953-62), and the availability of fluorogenic derivatives is essential for the rapid construction of “turn-on” reactive probes for chemoselective bioimaging. However, these fluorescent anilines have been found to be unstable in aqueous physiological conditions due to the marked electrophilicity of their meso-position and hence its propensity to undergo nucleophilic attack by a water molecule or a hydroxyde anion. Further investigations have helped us to determine the acidic pH range at which the sulfone-rosamine 2 is fully-stable and a complete assessment of the photophysical properties could be performed. Its pro-fluorescent character and utility were then proved by the preparation and in vitro enzymatic activation of a penicillin G acylase (PGA) sensitive fluorogenic probe.
View MoreChengdu Gelipu Biotechnology Co., Ltd.
website:http://www.glp-china.com
Contact:86-28-82610909
Address:chegndu
Anhui Qingyun Pharmaceutical and Chemical Co.,Ltd
Contact:+86-551-63633067
Address:Shuangfeng Road Hefei Anhui
Xinxiang Hongqi District Houyuan Trading Co., Ltd
Contact:86-373-3695376
Address:Xinxiang City, Henan Province, China
Naturalin Bio-Resource Co., Ltd
website:http://www.naturalin.com
Contact:+86-0731-84430651
Address:B1-402, Lu-Valley Enterprise Square.No.27 Wenxuan Road. Lu-Valley Hi-Tech District.
Shanghai ZaiQi Bio-Tech Co., Ltd.,
Contact:+86-21-6722 0633
Address:Bldg. No.7, No.201 MinYi Rd,Songjiang CaoHeJing High-Tech Park Shanghai 201516 P,R,China
Doi:10.1007/BF02782201
()Doi:10.1039/d0ra01578d
(2020)Doi:10.1007/BF01179585
()Doi:10.1039/c2dt32310a
(2013)Doi:10.1177/1469066718820434
(2019)Doi:10.1080/00304940409355396
(2004)