Research on Chemical Intermediates p. 2525 - 2537 (2016)
Update date:2022-08-30
Topics:
Guo, Ying
Li, Yu-Dao
Chen, Cheng
Zhao, Jian-Hong
Liu, Hong-Wei
Liao, Dao-Hua
Ji, Ya-Fei
An efficient ligand-free fluoroalkoxylation of unactivated aryl bromides has been developed, with special attention focused on practicability of the reaction. Without precious metal and organic ligand, the reaction was carried out under the catalytic system of inexpensive copper(I) bromide as a catalyst, N,N-dimethyl formamide as a cocatalyst, and the corresponding stoichiometric sodium fluoroalkoxide as a nucleophilic reagent. The facile approach avoids the drawbacks associated with cost, separation and pollution of ligand to enable sustainable access to aryl fluoroalkyl ethers from readily available bromoarenes.
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