Bioorganic and Medicinal Chemistry p. 1848 - 1858 (2018)
Update date:2022-08-28
Topics:
Fadlan, Arif
Tanimoto, Hiroki
Ito, Tatsuya
Aritomi, Yusuke
Ueno, Maho
Tokuda, Masaya
Hirohara, Shiho
Obata, Makoto
Morimoto, Tsumoru
Kakiuchi, Kiyomi
The synthesis and characterization of a ‘complete set’ of positional isomers of tetrakis(perfluorophenyl)porphyrins (TFPP)-glucose conjugates (1OH, 2OH, 3OH, 4OH, and 6OH) are reported herein. The cellular uptake and photocytotoxicity of these conjugates were examined in order to investigate the influence of location of the TFPP moiety on the D-glucose molecule on the biological activity of the conjugates. An In vitro biological evaluation revealed that the certain of these isomers have a greater effect on cellular uptake and cytotoxicity than others. The TFPP-glucose conjugates 1OH, 3OH, and 4OH were found to exert exceptional photocytotoxicity in several types of cancer cells compared to 2OH and 6OH substituted isomers.
View MoreTaizhou Sunny Chemical Co.,Ltd
Contact:+86-523-86920899 +86-13951172783
Address:No.11 Xingyuang road, Gaoyong Chemical Industry Park, Gaogang Jiangsu China
Contact:410-273-7300; 800-221-3953
Address:4609 Richlynn Dr., PO Box 369, Belcamp, MD, 21017-0369, USA
Feiyang Biotechnology Co., Ltd.
Contact:+86-533-7866339
Address:Qilu Chemistry Park, 200m north of Management Community Building of Park
Anhui Asahikasei Chemical Co., Ltd
Contact:86-551-4259770
Address:No. 88 Linquan Road Hefei Anhui China
Zhuhai Rundu Pharmaceutical co.,Ltd
Contact:+86-756-7630755
Address:No.6,North Airport Road,Sanzao Town,Jinwan District
Doi:10.1021/acs.jmedchem.8b00931
(2018)Doi:10.1016/j.tetlet.2010.05.111
(2010)Doi:10.1002/ejoc.202001408
(2020)Doi:10.1021/acs.oprd.0c00145
(2020)Doi:10.1002/chem.201103508
(2012)Doi:10.1002/hlca.201500054
(2015)