3
We propose that the reaction begins with a Michael addition
that generates zwitterion A. Nucleophilic attack by the anionic
center onto the carbonyl group of the aroyl subunit leads to
closure of the five-membered ring. Intermediate В then reacts
through migration of the aryl group to the C-10a position to give
pyrrolo[2,1-a]isoquinolines 8–18.
Conclusion
In conclusion,
convenient, novel precursors for the synthesis of pyrrolo[2,1-
a]isoquinolines containing functional groups that are available
for further modification.
1-aroyl-3,4-dihydroisoquinolines
are
Acknowledgments
This work was supported by the Russian Foundation for Basic
Research (grant 14-03-00311 and 15-33-20187-mol_a_ved). This
paper was financially supported by the Ministry of Education and
Science of the Russian Federation on the program to improve the
competitiveness of RUDN University among the world’s leading
research and education centers in 2016-2020.
Supplementary data
References and notes
Scheme 3. Proposed mechanism for the formation of pyrrolo[2,1-
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