European Journal of Medicinal Chemistry p. 183 - 189 (2017)
Update date:2022-08-18
Topics:
Singh, Dhandeep
Silakari, Om
Series of benzotriazole derivatives were synthesized and evaluated for their Sodium hydrogen exchanger-1 inhibitory potential. All compounds inhibit Sodium hydrogen exchanger-1 in the in-vitro platelet swelling assay. This is perhaps the first report of NHE-1 inhibitory activity of benzotriazole. The 1-alkyl benzotriazole derivatives were found to be more active than the 2-alkyl isomers. The activity increases with increase in chain length of alkyl moiety. Potency increased from that of benzotriazole (IC50= 192.68 μM) to heptyl derivative (compound 13; IC50= 59.23 μM). Introduction of electronegative oxygen atom further increased potency as shown by the benzoyl (compound 16, IC50= 51.57 μM) and sulfonyl groups (compound 17, IC50= 50.89 μM; compound 18, IC50= 49.95 μM).
View MoreContact:+86-13666670345
Address:Agricultural Development Zone, Haining, Jiaxing, Zhejiang
QINGDAO TAOSIGN INTERNATIONAL TRADE CO.,LIMITED
Contact:+86-0532-82683616
Address:RM1402, Doublestar Seacoase 7#, No. 5 Guizhou Road, Qingdao, Shandong, China
LIAOYANG TENGYUAN FOOD ADDITIVE FACTORY
Contact:+86-419-5807666
Address:Haodianzi village,Hanling Town,Liaoyang county
LinHai Cina Chemical Co., LTD.
Contact:0576-85580989
Address:Pharma-chem zone,Duqiao,Linhai,Zhejiang,China
Contact:+86-15850770348
Address:51 OF XIANGFANGCUN ROAD, Nanjing 210002, China
Doi:10.1021/jm9810396
(1998)Doi:10.1007/BF01199650
()Doi:10.1002/hlca.19700530704
(1970)Doi:10.1016/j.tetlet.2006.12.111
(2007)Doi:10.1039/p19960002167
(1996)Doi:10.1016/0957-4166(95)00142-C
(1995)