ACETYLATION OF ALCOHOLS, PHENOLS, AND AMINES
1027
General Procedure
A mixture of the substrate (1 mmol), acetic anhydride (1 mmol), and MTSA
(0.3 mmol, 0.11 g) in CH2Cl2 (3 mL) was stirred at room temperature. After
completion of the reaction (monitored by thin-layer chromatography, TLC), the
mixture was filtered. The filtrate was washed with CH2Cl2 (5 mL). The organic layer
was washed with 5% solution of NaHCO3, then with water, and dried over MgSO4.
Evaporation of the solvent followed by column chromatography on silica gel
afforded the pure acetate.
ACKNOWLEDGMENT
We are thankful to the University of Guilan Research Council for the partial
support of this work.
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