Synthetic Communications p. 2867 - 2875 (2013)
Update date:2022-08-11
Topics:
Verma, Praveen Kumar
Kumar, Neeraj
Sharma, Upendra
Bala, Manju
Kumar, Vishal
Singh, Bikram
A transition metal-free process, promoted by sodium borohydride, has been developed for convenient and selective hydration of nitriles to corresponding amides. The present process converts the aromatic, aliphatic, and heteroaromatic nitriles with wide functional group tolerance. The regioselective hydration of one nitrile moiety in the presence of an other nitrile group makes high impact in the present protocol.
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