RSC Advances p. 6365 - 6371 (2015)
Update date:2022-08-11
Topics:
Veisi, Hojat
Maleki, Behrooz
Hamelian, Mona
Ashrafi, Samaneh Sedigh
A transition metal-free process, catalyzed by tetrabutylammonium hydroxide (TBAH), has been developed for the convenient and selective hydration of nitriles to the corresponding amides. The present process converts aromatic, aliphatic, and heteroaromatic nitriles with a wide variety of functional groups into amides. The regioselective hydration of one nitrile moiety in the presence of another nitrile group gives the present protocol high impact.
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