Applied Catalysis A: General p. 203 - 210 (2017)
Update date:2022-08-16
Topics:
Azuaje, Jhonny
Tubío, Carmen R.
Escalante, Luz
Gómez, Mónica
Guitián, Francisco
Coelho, Alberto
Caama?o, Olga
Gil, Alvaro
Sotelo, Eddy
A catalytic methodology is reported that enables the efficient, operationally simple and environmentally friendly synthesis of diverse 1,4-dihydropyridines and 3,4-dihydropyrimidin-2(1H)-ones, including some relevant drugs and pharmacologically active derivatives. This strategy is based on the use of a 3D printed Al2O3 woodpile material that was sintered to generate a rigid structure with controlled porosity and noteworthy catalytic performance. The 3D printed Al2O3 catalyst exhibits remarkable efficacy as a Lewis acid in Biginelli and Hantzsch reactions and it can be recovered and reused ten times without any decrease in the activity. Remarkable E factors, excellent recyclability and scalability, broad substrate scope, short reaction times, excellent yields, solvent-free conditions and easy isolation procedures are key features of this methodology.
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