Bioscience, Biotechnology and Biochemistry p. 1138 - 1141 (1997)
Update date:2022-08-22
Topics:
Nishioka, Tetsuo
Watanabe, Jun
Kawabata, Jun
Niki, Ryoya
A phenolic amide, N-p-coumaroyltyramine (1), was isolated as an α-glucosidase inhibitor from methanol extracts of Welsh onion (Allium fistulosum). The inhibitory activity of 1 against a yeast enzyme was as high as Ki 8.4 × 10-7 M. From a structure-activity relationship study of 1 and its related compounds, the occurrence of α-glucosidase inhibitory activity required a p-coumaramide structure, with an amide hydrogen and alkyl or aralkyl substituent on the amide part.
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