Organic Process Research & Development
ARTICLE
rate) were selected on the H-Cube hydrogenator. The instru-
ment was fitted with a 30 mm Ra/Ni CatCart and the processing
was started, whereby initially only pure solvent was pumped
through the system until the instrument had achieved the desired
reaction parameters and stable processing was achieved. At that
point the sample inlet line was switched to the vial containing the
substrate. A total reaction volume of 15 mL was collected and the
cartridge subsequently washed with pure solvent for 5 min to
remove any substrate/product still adsorbed on the catalyst.
Evaporation of the solvent affords 4-(4-hydroxyphenyl)-butan-2-
one (2c) as a yellow oil (97% crude yield), which was purified by
flash chromatography to provide 1.04 g of a pale yellow oil
(91%).1H NMR (300 MHz, CDCl3): δ = 2.14 (s, 3H),
2.70ꢀ2.75 (m, 2H), 2.80ꢀ2.86 (m, 2H), 4.86 (br s, 1H),
6.73ꢀ6.76 (m, 2H), 7.02ꢀ7.07 (m, 2H); MS (pos. ESI): m/z =
165 (Mþ).
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’ AUTHOR INFORMATION
Corresponding Author
*oliver.kappe@uni-graz.at
’ ACKNOWLEDGMENT
This work was supported by a grant from the Christian
Doppler Research Society (CDG).
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