Paper
Organic & Biomolecular Chemistry
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Conclusions
In summary, we have developed a sustainable and practical
approach for the green preparation of various O-alkylated
hydroximides (30 examples, 69–91% yield) through ultrasound
acceleration under transition metal-free and solvent-free con-
ditions. This reaction is also highly selective and has good
functional group tolerance. Moreover, these coupled
O-alkylated hydroximides are useful intermediates in organic
synthesis through the selective deprotection process.
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Experimental section
General experimental procedures for 3a
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In a vial, NHPI (0.5 mmol), diethyl ether (2.5 mmol), TBAI
(0.1 mmol) and TBHP (2.5 mmol) were added, and then the con-
tents were reacted under ultrasound irradiation (40 kHz/40 W).
Upon completion, the reaction mixture was purified by column
chromatography on silica gel (eluent: hexanes/ethyl acetate) to
afford 3a.
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Conflicts of interest
There are no conflicts to declare.
Acknowledgements
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5
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We thank the Hunan Province Science Foundation for Youths
(2018JJ3215), Research Foundation of Education Bureau of
Hunan Province (18C0147) and Hunan Agricultural University
Science Foundation for High-Level Personnel (17QN21),
Double first-class construction project of Hunan Agricultural
University. We are grateful for the financial support from the
National Natural Science Foundation of China (No. 31672457),
Local Science and Technology Development Project guided by
the Central Government (YDZX20184300002303), Ministry of
Agriculture of the People’s Republic of China (2015-Z64 and
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