Journal of Antibiotics p. 402 - 411 (1997)
Update date:2022-08-17
Topics:
Yamaji, Kayoko
Masubuchi, Miyako
Kawahara, Fumiko
Nakamura, Yumiko
Nishio, Aya
Matsukuma, Shoko
Fujimori, Mikako
Nakada, Naoki
Watanabe, Junko
Kamiyama, Tsutomu
DNA gyrase inhibitors, cyclothialidines B, C, D and E were isolated from four Streptomycete strains (NR 0659, NR 0660, NR 0661 and NR 0662). Their structures have been elucidated based on the amino acid analysis of the hydrolysates, NMR and HRFAB-MS experiments and shown to be cyclothialidine analogs. The absolute stereochemistry has been determined by the chiral HPLC analysis of the hydrolysates. Cyclothialidines B, D and E are novel and potent inhibitors of DNA gyrase.
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