Molecules p. 5882 - 5892 (2012)
Update date:2022-09-26
Topics:
Lima-Neto, Reginaldo G.
Cavalcante, Nery N. M.
Srivastava, Rajendra M.
Mendonca Jr., Francisco J. B.
Wanderley, Almir G.
Neves, Rejane P.
Dos Anjos, Janaina V.
1,2,3-Triazoles have been extensively studied as compounds possessing important biological activities. In this work, we describe the synthesis of ten 2-(1-aryl-1H- 1,2,3-triazol-4-yl)propan-2-ols via copper catalyzed azide alkyne cycloaddition (CuAAc or click chemistry). Next the in vitro antifungal activity of these ten compounds was evaluated using the microdilution broth method against 42 isolates of four different Candida species. Among all tested compounds, the halogen substituted triazole 2-[1-(4-chlorophenyl)-1H- (1,2,3)triazol-4-yl]propan-2-ol, revealed the best antifungal profile, showing that further modifications could be done in the structure to obtain a better drug candidate in the future.
View MoreTianjin Emulsion Science&Technology Development Co.,Ltd
Contact:13901380442
Address:Vake Garden New Town New Yi Bai Road Beichen District Tianjin,China
Zhejiang Kente Chemical Co.,Ltd.
Contact:86-0576-87651912
Address:No.7, Fengxi West Road, Modern Industrial Zone
Suzhou Lixin Pharmaceutical Co., Ltd.
Contact:86-512-88169812
Address:21 Tangxi Road, Suzhou New District, Suzhou 215151
Jinan Chenghuishuangda Chemical CO.,Ltd
website:http://www.jnchsd.com
Contact:+86-531-58897082
Address:No.2350, Kaituo Road, High-tech Development District, Jinan City, Shandong, China
website:http://www.chinabarton.com
Contact:+86-573-82719618
Address:No. 162 Fumin Road, Honghe Town,
Doi:10.1021/acs.orglett.9b00660
(2019)Doi:10.1021/jm960214k
(1996)Doi:10.1016/S0040-4039(00)98213-3
(1985)Doi:10.1055/s-0032-1318188
(2013)Doi:10.1039/b801109e
(2008)Doi:10.1016/j.bmcl.2008.04.078
(2008)