Tetrahedron Asymmetry p. 1063 - 1066 (1995)
Update date:2022-08-16
Topics:
Song
Lee
Lee
Lee
A new method for the preparation of (R)-carnitine (1) has been developed from enantiomerically pure (R)-4-(trichloromethyl)-oxetan-2-one [(R)-2] which was easily obtained from the [2 + 2]-cycloaddition of ketene and chloral in the presence of catalytic amounts of poly(acryloyl quinidine). The key intermediate, ethyl (R)-3-hydroxy-4-chlorobutyrate [(R)-5], was prepared by ethanolysis of (R)-2 followed by selective bis-dechlorination of ethyl (R)-3-hydroxy-4,4,4-trichlorobutyrate [(R)-3].
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