Bioorganic Chemistry p. 274 - 289 (2004)
Update date:2022-08-28
Topics:
Haidekker, Mark A.
Brady, Thomas P.
Chalian, Sevag H.
Akers, Walter
Lichlyter, Darcy
Theodorakis, Emmanuel A.
Recent research shows high potential for some p-N,N- dialkylaminobenzylidenecyanoacetates, part of a group known as fluorescent molecular rotors, to serve as fluorescent, non-mechanical viscosity sensors. Of particular interest are molecules compatible with aqueous environments. In this study, we present the synthesis and physical characterization of derivatives from 9-(2-carboxy-2-cyanovinyl)-julolidine and related molecules. All compounds show a power-law relationship of fluorescence emission with the viscosity of the solvent, different mixtures of ethylene glycol and glycerol to modulate viscosity. Compounds with high water solubility exhibit the same behavior in aqueous solutions of dextran, where the dextran concentration was varied to modulate viscosity. In addition, some compounds have been found to have low sensitivity towards changes in the pH in the physiological range. The compounds presented show promise to be used in biofluids, such as blood plasma or lymphatic fluid, to rapidly and non-mechanically determine viscosity.
View MoreYingkou Sanzheng New Technology Chemical Industry Co., Ltd.
Contact:+86-417-2927806
Address:yingkou
China Synchem Technology Co.,Ltd
website:http://www.cnsynchem.com
Contact:+86-0552-4929311
Address:No.217 Daqing Road
SHANGHAI RC CHEMICALS CO.,LTD.
website:http://www.rcc.net.cn
Contact:+86-21-50322175
Address:Rm1415 Yinqiao Masion No.58 Jinxin Road Pudong Shanghai China
shanghai hekang chemical co.ltd
Contact:021-54173790
Address:328 WuHe Road, Building #A, 2nd Floor, Minhang, Shanghai 201109, China
Jiangsu Dacheng Pharmaceutical and Chemical Co.,Ltd
Contact:+86-0517-87036900
Address:Chuzhou Chemical park, Huai'an, Jiangsu Province
Doi:10.1016/S0021-9517(02)00144-6
(2003)Doi:10.1021/jo00134a035
(1982)Doi:10.1016/j.cclet.2020.05.044
(2020)Doi:10.1016/j.molstruc.2021.131441
(2022)Doi:10.1081/SCC-100106209
(2001)Doi:10.1021/ic50225a079
(1981)