Organic Process Research and Development p. 1257 - 1262 (2015)
Update date:2022-08-10
Topics:
Zhang, Teng
Chen, Zhenxing
Tian, Yan
Han, Bin
Zhang, Ning
Song, Wei
Liu, Zhulan
Zhao, Jinli
Liu, Jianli
Kilogram-scale synthesis of a bioactive pentapeptide in solution by "3 + 2" fragment coupling strategy has been successively accomplished in the development of OGP (10-14), a minimal OGP-derived sequence that retains the full proliferative activity of the osteogenic growth peptide. The synthetic scheme, coupling conditions, and scaling-up of the process are systematically studied; the epimerization of the tripeptide fragment and pentapeptide are also evaluated.
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