Journal of labelled compounds and radiopharmaceuticals p. 1133 - 1145 (1995)
Update date:2022-08-30
Topics:
Hughes
Hartman
Jay
A series of hollow fiber membranes containing immobilized enzymes were prepared and used in the synthesis of 11C-labelled nucleosides. 11C-Formaldehyde was produced in an alcohol oxidase/catalase bioreactor and circulated through a thymidylate synthase bioreactor with an appropriate substrate to produce the corresponding 11C-nucleotide. These labelled nucleotides were subsequently dephosphorylated in an alkaIine phosphatase bioreactor. The bioreactor approach was amenable to hot-cell conditions and yielded 11C-products in higher yield and shorter synthesis times than conventional chemical approaches.
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